{"id":133,"date":"2024-04-19T16:25:58","date_gmt":"2024-04-19T07:25:58","guid":{"rendered":"https:\/\/cm-plus.co.jp\/vn\/?page_id=133"},"modified":"2025-09-25T14:56:04","modified_gmt":"2025-09-25T05:56:04","slug":"macromolecular_drugs","status":"publish","type":"page","link":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/","title":{"rendered":"Large-Molecule ( Biopharmaceutical ) API Manufacturing Facility"},"content":{"rendered":"<div id=\"macromolecular_drugs\">\n<div id=\"pagePath\">\n<ul>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/\">Trang ch\u1ee7<\/a>\/<\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/\">D\u1ecbch v\u1ee5<\/a>\/<\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/\">T\u01b0 v\u1ea5n K\u1ef9 thu\u1eadt, Qu\u1ea3n l\u00fd D\u1ef1 \u00e1n<\/a>\/<\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/\">Sectors<\/a>\/<\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/\">D\u01b0\u1ee3c ph\u1ea9m v\u00e0 Thi\u1ebft b\u1ecb Y t\u1ebf<\/a>\/<\/li>\n<li>C\u01a1 s\u1edf s\u1ea3n xu\u1ea5t API ph\u00e2n t\u1eed l\u1edbn (D\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc)<\/li>\n<\/ul>\n<\/div>\n<div class=\"h1Sub\">\n<div class=\"content\">\n<h1 class=\"h1Ttl\"><span class=\"subSpan\">D\u01b0\u1ee3c ph\u1ea9m v\u00e0 Thi\u1ebft b\u1ecb Y t\u1ebf<\/span><br class=\"wpTag\">C\u01a1 s\u1edf s\u1ea3n xu\u1ea5t <br \/>API ph\u00e2n t\u1eed l\u1edbn (D\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc)<br \/>\n<span class=\"h1Photo\"><br \/>\n<span class=\"maskBox\"><br \/>\n<span class=\"topCover\"><br \/>\n<img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp\" alt=\"Pharmaceuticals and Medical Devices Large-Molecule API Manufacturing Facility\"><br \/>\n<\/span><br \/>\n<span class=\"btmImg01\"><br \/>\n<img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/image-field05.webp\" alt=\"Pharmaceuticals and Medical Devices Large-Molecule API Manufacturing Facility\"><br \/>\n<\/span><br \/>\n<span class=\"btmImg02\"><br \/>\n<img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/image-field05.webp\" alt=\"Pharmaceuticals and Medical Devices Large-Molecule API Manufacturing Facility\"><br \/>\n<\/span><br \/>\n<\/span><br \/>\n<\/span><br \/>\n<\/h1>\n<\/div>\n<\/div>\n<div class=\"content\">\n<div class=\"mainBox\">\n<article id=\"conts\">\n<div class=\"comTableDBox\">\n<div class=\"innerBox\">\n<table class=\"tableD\">\n<thead>\n<tr>\n<th><span class=\"en\">Ph\u00e2n lo\u1ea1i<\/span><\/th>\n<th><span class=\"txt\">Ph\u00e2n t\u1eed l\u01b0\u1ee3ng th\u1ea5p<\/span><\/th>\n<th><span class=\"txt\">Ph\u00e2n t\u1eed l\u01b0\u1ee3ng trung b\u00ecnh<\/span><\/th>\n<th><span class=\"txt\">Ph\u00e2n t\u1eed l\u01b0\u1ee3ng cao<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th><span class=\"en\">Kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/span><\/th>\n<td>\n<p class=\"priceTxt\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/dot_img01.webp\" alt=\"\"><span class=\"wpTag\">\uff5e500<\/span><\/p>\n<\/td>\n<td>\n<p class=\"priceTxt\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/dot_img02.webp\" alt=\"\"><span class=\"wpTag\">500\uff5e2,000<\/span><\/p>\n<\/td>\n<td>\n<p class=\"priceTxt\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/dot_img03.webp\" alt=\"\"><span class=\"wpTag\">2,000\uff5e<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<th><span class=\"en\">V\u00ed d\u1ee5<\/span><\/th>\n<td>\n<ul class=\"txtUl\">\n<li>D\u01b0\u1ee3c ph\u1ea9m h\u1eefu c\u01a1 t\u1ed5ng h\u1ee3p<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul class=\"txtUl\">\n<li>D\u01b0\u1ee3c ph\u1ea9m Peptide<\/li>\n<li>D\u01b0\u1ee3c ph\u1ea9m axit nucleic<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul class=\"txtUl\">\n<li>Thu\u1ed1c kh\u00e1ng th\u1ec3<\/li>\n<li>V\u1eafc-xin<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<th><span class=\"en\">C\u00e1c Ph\u01b0\u01a1ng ph\u00e1p s\u1ea3n xu\u1ea5t ch\u00ednh<\/span><\/th>\n<td>\n<ul class=\"txtUl\">\n<li> T\u1ed5ng h\u1ee3p h\u1eefu c\u01a1<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul class=\"txtUl\">\n<li>T\u1ed5ng h\u1ee3p peptide<\/li>\n<li>T\u1ed5ng h\u1ee3p axit nucleic<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul class=\"txtUl\">\n<li>Nu\u00f4i c\u1ea5y vi sinh <\/li>\n<li>Nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"btmTxt\">API ph\u00e2n t\u1eed l\u1edbn ch\u1ee7 y\u1ebfu bao g\u1ed3m API nu\u00f4i c\u1ea5y vi sinh v\u1eadt v\u00e0 API nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt. C\u00e1c API n\u00e0y \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng c\u00e1ch k\u1ebft h\u1ee3p c\u00e1c k\u1ef9 thu\u1eadt nh\u01b0 t\u00e1i t\u1ed5 h\u1ee3p gen, ng\u00e2n h\u00e0ng t\u1ebf b\u00e0o, nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o, chi\u1ebft xu\u1ea5t v\u00e0 tinh ch\u1ebf \u0111\u1ec3 t\u1ea1o ra c\u00e1c th\u00e0nh ph\u1ea7n protein ho\u1ea1t \u0111\u1ed9ng. V\u00ed d\u1ee5 bao g\u1ed3m kh\u00e1ng th\u1ec3, enzyme, hormone v\u00e0 interferon. Ng\u01b0\u1eddi ta hy v\u1ecdng r\u1eb1ng ch\u00fang s\u1ebd gi\u1ea3i quy\u1ebft c\u00e1c nhu c\u1ea7u y t\u1ebf ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng, v\u1ed1n kh\u00f3 gi\u1ea3i quy\u1ebft b\u1eb1ng d\u01b0\u1ee3c ph\u1ea9m ph\u00e2n t\u1eed nh\u1ecf. V\u00ec c\u00e1c API n\u00e0y li\u00ean quan \u0111\u1ebfn vi\u1ec7c x\u1eed l\u00fd c\u00e1c sinh v\u1eadt v\u00e0 protein sinh h\u1ecdc, n\u00ean c\u1ea7n ph\u1ea3i \u0111\u1ea3m b\u1ea3o t\u00ednh v\u00f4 tr\u00f9ng c\u1ee7a c\u00e1c c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t v\u00e0 qu\u1ea3n l\u00fd c\u00e1c kh\u00eda c\u1ea1nh sinh h\u1ecdc c\u1ee7a c\u00e1c \u0111i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng.<\/p>\n<\/div>\n<div class=\"comBorBox\">\n<section class=\"sec01\">\n<h2 class=\"headLine05\">C\u00e1c lo\u1ea1i v\u00e0 \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a API ph\u00e2n t\u1eed l\u1edbn<\/h2>\n<h3 class=\"headLine06\">V\u1eadt li\u1ec7u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong d\u01b0\u1ee3c ph\u1ea9m ph\u00e2n t\u1eed l\u1edbn (sinh h\u1ecdc) v\u00e0 d\u01b0\u1ee3c ph\u1ea9m ch\u00ednh<\/h3>\n<table class=\"tableB\">\n<thead>\n<tr>\n<th class=\"wid01\">&nbsp;<\/th>\n<th colspan=\"2\" class=\"wid02\">Nguy\u00ean li\u1ec7u<\/th>\n<th>D\u01b0\u1ee3c ph\u1ea9m ch\u00ednh<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th rowspan=\"5\"><span class=\"en pcEn\">T\u1ebf b\u00e0o ch\u1ee7<\/span><\/th>\n<td><strongT\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt<\/strong><\/td>\n<td class=\"tdStyle01\">CHO, SP2\/0, NS0, Human Cells (HT1080, HEK), etc.<\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>C\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u<\/li>\n<li>Erythropoietin<\/li>\n<li>Kh\u00e1ng th\u1ec3<\/li>\n<li>Enzym lysosome<\/li>\n<li>Protein h\u1ee3p nh\u1ea5t Fc<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\"><strong>Vi sinh v\u1eadt<\/strong><\/td>\n<td class=\"tdStyle01\">E. coli<\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>Insulin<\/li>\n<li>Hormone t\u0103ng tr\u01b0\u1edfng<\/li>\n<li>Interferon<\/li>\n<li>Cytokines<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"tdStyle01\">Enzymes<\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>Insulin<\/li>\n<li>Glucagon<\/li>\n<li>Albumin huy\u1ebft thanh ng\u01b0\u1eddi<\/li>\n<li>V\u1eafc-xin HPV<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><strong>T\u1ebf b\u00e0o c\u00f4n tr\u00f9ng<\/strong><\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>V\u1eafc-xin HPV<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u1ebf b\u00e0o th\u1ef1c v\u1eadt<\/strong><\/td>\n<td class=\"tdStyle01\">G\u1ea1o, thu\u1ed1c l\u00e1, c\u00e0 r\u1ed1t<\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>Lactoferrin t\u00e1i t\u1ed5 h\u1ee3p<\/li>\n<li>V\u1eafc-xin c\u00fam<\/li>\n<li>Kh\u00e1ng th\u1ec3 ch\u1ed1ng vi-r\u00fat Ebola t\u00e1i t\u1ed5 h\u1ee3p<\/li>\n<li>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh Gaucher<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<th rowspan=\"3\"><span class=\"en pcEn\">T\u1ebf b\u00e0o ngu\u1ed3n<\/span><\/th>\n<td colspan=\"2\"><strong>\u0110\u1ed9ng v\u1eadt<\/strong><\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>Heparin<\/li>\n<li>Hyaluronic Acid<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><strong>Th\u1ef1c v\u1eadt<\/strong><\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>C\u00e2y thu\u1ed1c<\/li>\n<li>Morphine<\/li>\n<li>Aspirin<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><strong>Huy\u1ebft t\u01b0\u01a1ng<\/strong><\/td>\n<td>\n<ul class=\"comRaiList\">\n<li>Immunoglobulin<\/li>\n<li>Albumin<\/li>\n<li>C\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u<\/li>\n<li>Fibrinogen<\/li>\n<li>Antithrombin<\/li>\n<li>Haptoglobin<\/li>\n<li>Thu\u1ed1c \u0111\u1eb7c tr\u1ecb b\u1ec7nh hi\u1ebfm<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"headLine06\">API nu\u00f4i c\u1ea5y vi sinh v\u1eadt<\/h3>\n<p class=\"comTxt\">Nu\u00f4i c\u1ea5y vi sinh v\u1eadt c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c chia th\u00e0nh nu\u00f4i c\u1ea5y s\u1eed d\u1ee5ng vi sinh v\u1eadt t\u1ef1 nhi\u00ean v\u00e0 nu\u00f4i c\u1ea5y s\u1eed d\u1ee5ng vi sinh v\u1eadt bi\u1ebfn \u0111\u1ed5i gen. Nu\u00f4i c\u1ea5y sau li\u00ean quan \u0111\u1ebfn vi\u1ec7c bi\u1ebfn \u0111\u1ed5i gen c\u00e1c vi sinh v\u1eadt nh\u01b0 E. coli v\u00e0 n\u1ea5m men \u0111\u1ec3 k\u1ebft h\u1ee3p c\u00e1c gen m\u00e3 h\u00f3a cho c\u00e1c ch\u1ea5t mong mu\u1ed1n (API) v\u00e0 sau \u0111\u00f3 s\u1ea3n xu\u1ea5t (bi\u1ec3u hi\u1ec7n) c\u00e1c ch\u1ea5t n\u00e0y trong vi sinh v\u1eadt, sau \u0111\u00f3 l\u00e0 tinh ch\u1ebf. Vi\u1ec7c x\u1eed l\u00fd vi sinh v\u1eadt bi\u1ebfn \u0111\u1ed5i gen ph\u1ea3i tu\u00e2n theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 Cartagena v\u1ec1 An to\u00e0n sinh h\u1ecdc. Trong khi vi sinh v\u1eadt t\u01b0\u01a1ng \u0111\u1ed1i d\u1ec5 x\u1eed l\u00fd v\u00e0 nu\u00f4i c\u1ea5y h\u00e0ng lo\u1ea1t, th\u00ec vi\u1ec7c bi\u1ec3u hi\u1ec7n c\u00e1c ch\u1ea5t mong mu\u1ed1n \u1edf d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng l\u1ea1i r\u1ea5t kh\u00f3 kh\u0103n. Do \u0111\u00f3, ch\u00fang ph\u00f9 h\u1ee3p h\u01a1n \u0111\u1ec3 s\u1ea3n xu\u1ea5t c\u00e1c protein c\u00f3 c\u1ea5u tr\u00fac \u0111\u01a1n gi\u1ea3n, nh\u1ecf.<\/p>\n<h3 class=\"headLine06\">API nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt<\/h3>\n<p class=\"comTxt\">T\u01b0\u01a1ng t\u1ef1 nh\u01b0 API nu\u00f4i c\u1ea5y vi sinh v\u1eadt, API nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 DNA t\u00e1i t\u1ed5 h\u1ee3p. C\u00e1c API n\u00e0y \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng c\u00e1ch bi\u1ec3u hi\u1ec7n c\u00e1c ch\u1ea5t \u0111i\u1ec1u tr\u1ecb trong t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt ch\u1ee7 nh\u01b0 t\u1ebf b\u00e0o CHO ho\u1eb7c t\u1ebf b\u00e0o COS, sau \u0111\u00f3 l\u00e0 tinh ch\u1ebf. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y ph\u00f9 h\u1ee3p \u0111\u1ec3 s\u1ea3n xu\u1ea5t c\u00e1c protein c\u00f3 tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed cao v\u1edbi c\u1ea5u tr\u00fac ph\u1ee9c t\u1ea1p, bao g\u1ed3m c\u1ea3 nh\u1eefng protein c\u00f3 glycosyl h\u00f3a. M\u1eb7c d\u00f9 t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt kh\u00f3 x\u1eed l\u00fd h\u01a1n v\u00e0 nu\u00f4i c\u1ea5y ch\u00fang \u0111\u00f2i h\u1ecfi s\u1ef1 ki\u1ec3m so\u00e1t ti\u00ean ti\u1ebfn, c\u00e1c ch\u1ea5t thu \u0111\u01b0\u1ee3c c\u00f3 th\u1ec3 m\u00f4 ph\u1ecfng ch\u1eb7t ch\u1ebd c\u00e1c d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng t\u1ef1 nhi\u00ean c\u1ee7a ch\u00fang, bao g\u1ed3m c\u00e1c c\u1ea5u tr\u00fac b\u1eadc ba v\u00e0 glycosyl h\u00f3a. So v\u1edbi nu\u00f4i c\u1ea5y vi sinh v\u1eadt, vi\u1ec7c s\u1ea3n xu\u1ea5t m\u1ed9t m\u1ebb duy nh\u1ea5t th\u01b0\u1eddng m\u1ea5t nhi\u1ec1u th\u1eddi gian h\u01a1n v\u00e0 \u0111\u00f2i h\u1ecfi m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y \u0111\u1eaft ti\u1ec1n v\u00e0 nh\u1ef1a s\u1eafc k\u00fd \u0111\u1ec3 tinh ch\u1ebf.<\/p>\n<h3 class=\"headLine06\">V\u1eafc-xin<\/h3>\n<p class=\"comTxt\">V\u1eafc-xin l\u00e0 c\u00e1c ch\u1ebf ph\u1ea9m \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 t\u1ea1o ra kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh trong c\u01a1 th\u1ec3. Vi\u1ec7c s\u1ea3n xu\u1ea5t v\u1eafc-xin ch\u1ec9 gi\u1edbi h\u1ea1n \u1edf c\u00e1c c\u01a1 s\u1edf do ch\u00ednh ph\u1ee7 ch\u1ec9 \u0111\u1ecbnh v\u00e0 ph\u1ea3i v\u01b0\u1ee3t qua c\u00e1c cu\u1ed9c ki\u1ec3m tra qu\u1ed1c gia tr\u01b0\u1edbc khi \u0111\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng. Nh\u00ecn chung, c\u00f3 hai lo\u1ea1i v\u1eafc-xin: v\u1eafc-xin s\u1ed1ng v\u00e0 v\u1eafc-xin b\u1ea5t ho\u1ea1t. V\u1eafc-xin b\u1ea5t ho\u1ea1t an to\u00e0n h\u01a1n nh\u01b0ng k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n v\u1eafc-xin s\u1ed1ng, do \u0111\u00f3, ng\u01b0\u1eddi ta th\u01b0\u1eddng th\u00eam t\u00e1 d\u01b0\u1ee3c \u0111\u1ec3 t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a v\u1eafc-xin.<\/p>\n<h3 class=\"headLine06\">S\u1ea3n ph\u1ea9m m\u00e1u<\/h3>\n<p class=\"comTxt\">S\u1ea3n ph\u1ea9m m\u00e1u l\u00e0 d\u01b0\u1ee3c ph\u1ea9m s\u1eed d\u1ee5ng c\u00e1c th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u00e1u ng\u01b0\u1eddi v\u00e0 bao g\u1ed3m c\u00e1c s\u1ea3n ph\u1ea9m truy\u1ec1n m\u00e1u v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb huy\u1ebft t\u01b0\u01a1ng. C\u00e1c s\u1ea3n ph\u1ea9m truy\u1ec1n m\u00e1u bao g\u1ed3m m\u00e1u to\u00e0n ph\u1ea7n ho\u1eb7c c\u00e1c th\u00e0nh ph\u1ea7n t\u00e1ch bi\u1ec7t nh\u01b0 h\u1ed3ng c\u1ea7u, ti\u1ec3u c\u1ea7u v\u00e0 huy\u1ebft t\u01b0\u01a1ng. C\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb huy\u1ebft t\u01b0\u01a1ng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng c\u00e1ch t\u00e1ch v\u00e0 tinh ch\u1ebf protein trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 bao g\u1ed3m c\u00e1c ch\u1ebf ph\u1ea9m albumin, ch\u1ebf ph\u1ea9m immunoglobulin, c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ec7nh hi\u1ebfm g\u1eb7p. T\u1ea5t c\u1ea3 c\u00e1c v\u1eadt li\u1ec7u m\u00e1u th\u00f4 \u0111\u1ec1u \u0111\u01b0\u1ee3c thu th\u1eadp t\u1eeb c\u00e1c l\u1ea7n hi\u1ebfn t\u1eb7ng v\u00e0 ph\u00e2n ph\u1ed1i cho ba nh\u00e0 s\u1ea3n xu\u1ea5t trong n\u01b0\u1edbc th\u00f4ng qua H\u1ed9i Ch\u1eef th\u1eadp \u0111\u1ecf Nh\u1eadt B\u1ea3n. Ngo\u1ea1i tr\u1eeb immunoglobulin, c\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb huy\u1ebft t\u01b0\u01a1ng kh\u00e1c \u0111\u1ec1u c\u00f3 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t th\u00f4ng qua nu\u00f4i c\u1ea5y v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c, v\u00e0 c\u1ea7n ph\u1ea3i xem x\u00e9t hi\u1ec7u qu\u1ea3 s\u1ea3n xu\u1ea5t v\u1edbi s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa cung v\u00e0 c\u1ea7u v\u1ec1 m\u00e1u th\u00f4 \u0111\u1ed1i v\u1edbi c\u00e1c s\u1ea3n ph\u1ea9m m\u00e1u.<\/p>\n<h3 class=\"headLine06\">API c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb \u0111\u1ed9ng v\u1eadt<\/h3>\n<p class=\"comTxt\">API c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb \u0111\u1ed9ng v\u1eadt, ngo\u1ea1i tr\u1eeb nh\u1eefng API \u0111\u01b0\u1ee3c \u0111\u1ec1 c\u1eadp trong &#8220;API nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt&#8221; v\u00e0 &#8220;S\u1ea3n ph\u1ea9m m\u00e1u&#8221;, l\u00e0 nh\u1eefng ch\u1ea5t kh\u00f3 s\u1ea3n xu\u1ea5t b\u1eb1ng t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc ho\u1eb7c k\u1ef9 thu\u1eadt di truy\u1ec1n. Ch\u00fang ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t v\u00e0 tinh ch\u1ebf t\u1eeb c\u00e1c c\u01a1 quan (nh\u01b0 ru\u1ed9t non, tuy\u1ebfn t\u1ee5y, nhau thai) c\u1ee7a gia s\u00fac v\u00e0 l\u1ee3n, v\u1edbi heparin l\u00e0 m\u1ed9t v\u00ed d\u1ee5 n\u1ed5i ti\u1ebfng. \u0110\u1ea3m b\u1ea3o an to\u00e0n cho nguy\u00ean li\u1ec7u th\u00f4 l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ed1i v\u1edbi API c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb \u0111\u1ed9ng v\u1eadt v\u00e0 h\u1ed3 s\u01a1 v\u1ec1 \u0111i\u1ec1u ki\u1ec7n ch\u0103n nu\u00f4i v\u00e0 gi\u1ebft m\u1ed5 c\u1ee7a \u0111\u1ed9ng v\u1eadt ngu\u1ed3n ph\u1ea3i \u0111\u01b0\u1ee3c l\u01b0u gi\u1eef t\u1ed1t. C\u00e1c bi\u1ec7n ph\u00e1p ch\u1ed1ng l\u1ea1i c\u00e1c b\u1ec7nh do prion nh\u01b0 B\u1ec7nh n\u00e3o x\u1ed1p \u1edf b\u00f2 (BSE) \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng.<\/p>\n<h3 class=\"headLine06\">D\u01b0\u1ee3c ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ef1c v\u1eadt<\/h3>\n<p class=\"comTxt\">C\u00e1c lo\u1ea1i d\u01b0\u1ee3c ph\u1ea9m n\u00e0y s\u1eed d\u1ee5ng c\u00e1c th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u00f3 trong th\u1ef1c v\u1eadt v\u00e0 bao g\u1ed3m c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c v\u00e0 thu\u1ed1c y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c, \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1eeb th\u1eddi c\u1ed5 \u0111\u1ea1i. C\u00e1c v\u00ed d\u1ee5 n\u1ed5i ti\u1ebfng bao g\u1ed3m thu\u1ed1c gi\u1ea3m \u0111au morphine c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e2y anh t\u00fac v\u00e0 aspirin t\u1eeb c\u00e2y li\u1ec5u. Thu\u1ed1c y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng theo \u0111\u01a1n k\u1ebft h\u1ee3p nhi\u1ec1u lo\u1ea1i thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c (c\u00f4ng th\u1ee9c). C\u00e1c ph\u01b0\u01a1ng ph\u00e1p s\u1ea3n xu\u1ea5t chung bao g\u1ed3m vi\u1ec7c l\u1ef1a ch\u1ecdn c\u00e1c b\u1ed9 ph\u1eadn c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh, s\u1ea5y kh\u00f4, nghi\u1ec1n, chi\u1ebft xu\u1ea5t, c\u00f4 \u0111\u1eb7c, tinh ch\u1ebf v\u00e0 pha tr\u1ed9n nhi\u1ec1u quy tr\u00ecnh kh\u00e1c nhau.<\/p>\n<\/section>\n<section class=\"sec02\">\n<h2 class=\"headLine05\">C\u01a1 s\u1edf s\u1ea3n xu\u1ea5t API ph\u00e2n t\u1eed l\u1edbn (d\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc): C\u00e1c \u0111i\u1ec3m ch\u00ednh \u0111\u1ec3 thi c\u00f4ng<\/h2>\n<div class=\"comGrayImgBox\">\n<h3 class=\"headLine06\">Quy ho\u1ea1ch c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/service\/engineering\/industrial_field\/pharma_medical-device_cosmetic\/macromolecular_drugs\/mark01.webp\" alt=\"Planning of Manufacturing Facilities\"><\/div>\n<div class=\"txtInn\">\n<p class=\"wpTag\">C\u00e1c c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t d\u01b0\u1ee3c ph\u1ea9m ph\u00e2n t\u1eed l\u1edbn bao g\u1ed3m c\u00e1c khu v\u1ef1c d\u00e0nh cho ho\u1ea1t \u0111\u1ed9ng t\u00e1i t\u1ed5 h\u1ee3p gen v\u00e0 x\u00e2y d\u1ef1ng ng\u00e2n h\u00e0ng t\u1ebf b\u00e0o ch\u00ednh, khu v\u1ef1c nu\u00f4i c\u1ea5y v\u00e0 tinh ch\u1ebf, v\u00e0 khu v\u1ef1c pha ch\u1ebf. M\u1ed7i khu v\u1ef1c ph\u1ea3i duy tr\u00ec m\u00f4i tr\u01b0\u1eddng s\u1ea1ch s\u1ebd \u0111\u1ec3 ng\u0103n ng\u1eeba \u00f4 nhi\u1ec5m t\u1ebf b\u00e0o. C\u00e1c c\u01a1 s\u1edf c\u0169ng ph\u1ea3i gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 qu\u1ea3n l\u00fd trang ph\u1ee5c cho nh\u00e2n vi\u00ean, ra v\u00e0o, x\u1eed l\u00fd v\u1eadt li\u1ec7u v\u00e0 c\u00e1c ch\u1ea5t nguy hi\u1ec3m. Trong khu v\u1ef1c s\u1ea3n xu\u1ea5t, ph\u1ea3i l\u1eafp \u0111\u1eb7t c\u00e1c thi\u1ebft b\u1ecb nh\u01b0 b\u0103ng gh\u1ebf s\u1ea1ch, t\u1ee7 an to\u00e0n, m\u00e1y \u1ea5p, m\u00e1y ly t\u00e2m, thi\u1ebft b\u1ecb nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o, th\u00f9ng ch\u1ee9a nit\u01a1 l\u1ecfng v\u00e0 thi\u1ebft b\u1ecb kh\u1eed tr\u00f9ng.<\/p>\n<\/div>\n<\/div>\n<h3 class=\"headLine06\">M\u1edf r\u1ed9ng quy m\u00f4<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/service\/engineering\/industrial_field\/pharma_medical-device_cosmetic\/macromolecular_drugs\/mark02.webp\" alt=\"Scale-Up\"><\/div>\n<div class=\"txtInn\">\n<p class=\"wpTag\">Khi qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n ti\u1ebfn tri\u1ec3n t\u1eeb kh\u00e1m ph\u00e1 thu\u1ed1c \u0111\u1ebfn th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 th\u01b0\u01a1ng m\u1ea1i h\u00f3a, qu\u00e1 tr\u00ecnh m\u1edf r\u1ed9ng quy m\u00f4 chuy\u1ec3n t\u1eeb c\u1ed1c th\u1ee7y tinh sang ph\u00f2ng th\u00ed nghi\u1ec7m (\u0111\u00f4i khi \u0111\u01b0\u1ee3c g\u1ecdi chung l\u00e0 ph\u00f2ng th\u00ed nghi\u1ec7m kilo), \u0111\u1ebfn th\u00ed \u0111i\u1ec3m, ra m\u1eaft v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 quy m\u00f4 th\u01b0\u01a1ng m\u1ea1i. \u0110\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m v\u00e0 hi\u1ec7u qu\u1ea3 s\u1ea3n xu\u1ea5t trong qu\u00e1 tr\u00ecnh m\u1edf r\u1ed9ng quy m\u00f4 n\u00e0y l\u00e0 r\u1ea5t quan tr\u1ecdng. Vi\u1ec7c m\u1edf r\u1ed9ng quy m\u00f4 t\u1eeb quy m\u00f4 ph\u00f2ng th\u00ed nghi\u1ec7m sang quy m\u00f4 s\u1ea3n xu\u1ea5t kh\u00f4ng ch\u1ec9 \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft b\u1eb1ng c\u00e1ch t\u0103ng th\u1ec3 t\u00edch ho\u1eb7c th\u1eddi gian trong l\u00f2 ph\u1ea3n \u1ee9ng. M\u1eb7c d\u00f9 c\u00f3 nh\u1eefng c\u00e1ch ti\u1ebfp c\u1eadn c\u01a1 b\u1ea3n \u0111\u1ec3 thi\u1ebft l\u1eadp th\u00f4ng s\u1ed1 v\u00e0 c\u00f4ng th\u1ee9c t\u00ednh to\u00e1n, nh\u01b0ng n\u0103ng su\u1ea5t mong \u0111\u1ee3i th\u01b0\u1eddng kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c. Do \u0111\u00f3, c\u1ea7n ph\u1ea3i th\u1eed nghi\u1ec7m v\u00e0 sai s\u00f3t trong c\u00e1c th\u00ed nghi\u1ec7m m\u1edf r\u1ed9ng quy m\u00f4 (ph\u00e1t tri\u1ec3n quy tr\u00ecnh). M\u1eb7c d\u00f9 \u0111i\u1ec1u n\u00e0y ph\u1ed5 bi\u1ebfn \u0111\u1ed1i v\u1edbi c\u1ea3 API ph\u00e2n t\u1eed nh\u1ecf \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc v\u00e0 API ph\u00e2n t\u1eed l\u1edbn li\u00ean quan \u0111\u1ebfn nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o, nh\u01b0ng n\u00f3 tinh t\u1ebf h\u01a1n \u0111\u1ed1i v\u1edbi API ph\u00e2n t\u1eed l\u1edbn. Sau khi \u0111\u00e1nh gi\u00e1 t\u1ea1i c\u00e1c nh\u00e0 m\u00e1y th\u00ed \u0111i\u1ec3m, thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t th\u01b0\u01a1ng m\u1ea1i \u0111\u01b0\u1ee3c ch\u1ebf t\u1ea1o v\u00e0 ph\u1ea3i ph\u1ea3n \u00e1nh \u0111\u1ea7y \u0111\u1ee7 c\u00e1c y\u00eau c\u1ea7u t\u1eeb qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n quy tr\u00ecnh.<\/p>\n<\/div>\n<\/div>\n<h3 class=\"headLine06\">L\u1ecbch tr\u00ecnh ho\u1ea1t \u0111\u1ed9ng<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/service\/engineering\/industrial_field\/pharma_medical-device_cosmetic\/macromolecular_drugs\/mark03.webp\" alt=\"Operational Schedule\"><\/div>\n<div class=\"txtInn\">\n<p class=\"wpTag\">\u0110\u1ed1i v\u1edbi API nu\u00f4i c\u1ea5y, quy tr\u00ecnh s\u1ea3n xu\u1ea5t \u0111\u01b0\u1ee3c chia th\u00e0nh quy tr\u00ecnh nu\u00f4i c\u1ea5y (ng\u01b0\u1ee3c d\u00f2ng) v\u00e0 quy tr\u00ecnh tinh ch\u1ebf (xu\u00f4i d\u00f2ng). Quy tr\u00ecnh nu\u00f4i c\u1ea5y di\u1ec5n ra trong v\u00e0i ng\u00e0y \u0111\u1ebfn kho\u1ea3ng m\u1ed9t th\u00e1ng trong m\u1ed9t thi\u1ebft b\u1ecb duy nh\u1ea5t (l\u00f2 ph\u1ea3n \u1ee9ng sinh h\u1ecdc), trong khi quy tr\u00ecnh tinh ch\u1ebf th\u01b0\u1eddng v\u1eadn h\u00e0nh t\u1eebng thi\u1ebft b\u1ecb trong m\u1ed9t ng\u00e0y. \u0110\u1ec3 t\u0103ng hi\u1ec7u qu\u1ea3 ho\u1ea1t \u0111\u1ed9ng v\u00e0 tr\u00e1nh c\u00e1c th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt thi\u1ebft k\u1ebf qu\u00e1 m\u1ee9c, quy tr\u00ecnh nu\u00f4i c\u1ea5y th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn nhi\u1ec1u h\u1ec7 th\u1ed1ng cho m\u1ed7i h\u1ec7 th\u1ed1ng tinh ch\u1ebf. Thi\u1ebft k\u1ebf v\u00e0 v\u1eadn h\u00e0nh thi\u1ebft b\u1ecb t\u1ed1i \u01b0u \u0111\u00f2i h\u1ecfi m\u1ed9t l\u1ecbch tr\u00ecnh ho\u1ea1t \u0111\u1ed9ng bao g\u1ed3m th\u1eddi gian t\u00e1i t\u1ea1o v\u00e0 c\u00e2n b\u1eb1ng c\u1ed9t v\u00e0 C\/SIP.<\/p>\n<\/div>\n<\/div>\n<h3 class=\"headLine06\">C\/SIP<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/service\/engineering\/industrial_field\/pharma_medical-device_cosmetic\/macromolecular_drugs\/mark04.webp\" alt=\"C\/SIP\"><\/div>\n<div class=\"txtInn\">\n<p class=\"wpTag\">H\u1ec7 th\u1ed1ng v\u1ec7 sinh t\u1ea1i ch\u1ed7 (CIP) v\u00e0 kh\u1eed tr\u00f9ng t\u1ea1i ch\u1ed7 (SIP) l\u00e0m s\u1ea1ch v\u00e0 kh\u1eed tr\u00f9ng thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t m\u00e0 kh\u00f4ng c\u1ea7n th\u00e1o r\u1eddi ho\u1eb7c di d\u1eddi. CIP s\u1eed d\u1ee5ng n\u01b0\u1edbc ho\u1eb7c dung d\u1ecbch v\u1ec7 sinh c\u00f3 ch\u1ee9a axit, baz\u01a1 ho\u1eb7c ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng b\u1ec1 m\u1eb7t \u0111\u1ec3 l\u00e0m s\u1ea1ch b\u1ec1 m\u1eb7t b\u00ean trong c\u1ee7a thi\u1ebft b\u1ecb v\u00e0 \u0111\u01b0\u1eddng \u1ed1ng. \u0110i\u1ec1u c\u1ea7n thi\u1ebft l\u00e0 ph\u1ea3i phun dung d\u1ecbch v\u1ec7 sinh v\u00e0 n\u01b0\u1edbc r\u1eeda l\u00ean t\u1ea5t c\u1ea3 c\u00e1c b\u1ec1 m\u1eb7t v\u00e0 lo\u1ea1i b\u1ecf c\u1eb7n b\u1ea9n b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c qu\u1ea3 c\u1ea7u phun. Vi\u1ec7c v\u1ec7 sinh \u0111\u01b0\u1eddng \u1ed1ng b\u00ean trong \u0111\u1ea3m b\u1ea3o hi\u1ec7u su\u1ea5t v\u1ec7 sinh \u0111\u01b0\u1ee3c duy tr\u00ec b\u1eb1ng c\u00e1ch \u0111\u1ea3m b\u1ea3o l\u01b0u l\u01b0\u1ee3ng v\u00e0 lo\u1ea1i b\u1ecf c\u00e1c kho\u1ea3ng kh\u00f4ng gian ch\u1ebft. SIP kh\u1eed tr\u00f9ng b\u00ean trong thi\u1ebft b\u1ecb v\u00e0 \u0111\u01b0\u1eddng \u1ed1ng b\u1eb1ng c\u00e1ch l\u00e0m n\u00f3ng h\u1ec7 th\u1ed1ng b\u1eb1ng h\u01a1i n\u01b0\u1edbc b\u00e3o h\u00f2a (h\u01a1i tinh khi\u1ebft) c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb n\u01b0\u1edbc tinh khi\u1ebft. M\u1eb7c d\u00f9 C\/SIP cung c\u1ea5p kh\u1ea3 n\u0103ng v\u1ec7 sinh v\u00e0 kh\u1eed tr\u00f9ng c\u00f3 th\u1ec3 t\u00e1i t\u1ea1o so v\u1edbi vi\u1ec7c th\u00e1o r\u1eddi thi\u1ebft b\u1ecb, nh\u01b0ng n\u00f3 l\u00e0m ph\u1ee9c t\u1ea1p h\u1ec7 th\u1ed1ng v\u00e0 t\u0103ng chi ph\u00ed ban \u0111\u1ea7u.<\/p>\n<\/div>\n<\/div>\n<h3 class=\"headLine06\">C\u00f4ng ngh\u1ec7 d\u00f9ng m\u1ed9t l\u1ea7n<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/service\/engineering\/industrial_field\/pharma_medical-device_cosmetic\/macromolecular_drugs\/mark05.webp\" alt=\"Single-Use Technology\"><\/div>\n<div class=\"txtInn\">\n<p class=\"wpTag\">Do y\u00eau c\u1ea7u cao v\u1ec1 \u0111\u1ed9 s\u1ea1ch v\u00e0 ti\u1ec7t tr\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc v\u00e0 v\u1eafc-xin, c\u00f4ng ngh\u1ec7 d\u00f9ng m\u1ed9t l\u1ea7n, tr\u00e1nh nhu c\u1ea7u v\u1ec7 sinh v\u00e0 ti\u1ec7t tr\u00f9ng, c\u00f3 hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi s\u1ea3n xu\u1ea5t giai \u0111o\u1ea1n \u0111\u1ea7u v\u00e0 s\u1ea3n xu\u1ea5t nhi\u1ec1u s\u1ea3n ph\u1ea9m. C\u00f4ng ngh\u1ec7 d\u00f9ng m\u1ed9t l\u1ea7n, t\u1eeb thi\u1ebft b\u1ecb tr\u1ed9n \u0111\u01a1n gi\u1ea3n \u0111\u1ebfn thi\u1ebft b\u1ecb nu\u00f4i c\u1ea5y v\u00e0 m\u00e1y khu\u1ea5y, c\u00f3 s\u1eb5n r\u1ed9ng r\u00e3i. C\u00e1c b\u1ed9 ph\u1eadn d\u00f9ng m\u1ed9t l\u1ea7n, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ed9 ph\u1eadn nu\u00f4i c\u1ea5y, tinh ch\u1ebf, \u0111i\u1ec1u ch\u1ec9nh m\u00f4i tr\u01b0\u1eddng, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9 pH, b\u1ea5t ho\u1ea1t, l\u1ecdc v\u00e0 \u0111\u1ea7u n\u1ed1i, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p \u0111\u1ec3 t\u1ea1o ra c\u00e1c quy tr\u00ecnh ho\u00e0n to\u00e0n t\u1ef1 \u0111\u1ed9ng. Tuy nhi\u00ean, c\u1ea7n c\u00f3 kh\u00f4ng gian l\u01b0u tr\u1eef l\u1edbn h\u01a1n. C\u1ea7n ti\u1ebfn h\u00e0nh \u0111\u00e1nh gi\u00e1 r\u1ee7i ro k\u1ef9 l\u01b0\u1ee1ng v\u1ec1 t\u00ednh v\u00f4 tr\u00f9ng, kh\u1ea3 n\u0103ng chi\u1ebft xu\u1ea5t, t\u00ednh to\u00e0n v\u1eb9n v\u00e0 ph\u01b0\u01a1ng ph\u00e1p k\u1ebft n\u1ed1i gi\u1eefa c\u00e1c quy tr\u00ecnh c\u1ee7a thi\u1ebft b\u1ecb d\u00f9ng m\u1ed9t l\u1ea7n. Tuy nhi\u00ean, n\u00f3 \u0111\u01a1n gi\u1ea3n h\u00f3a v\u00e0 l\u00e0m cho vi\u1ec7c ch\u1ebf t\u1ea1o thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t linh ho\u1ea1t h\u01a1n b\u1eb1ng c\u00e1ch lo\u1ea1i b\u1ecf thi\u1ebft b\u1ecb li\u00ean quan \u0111\u1ebfn v\u1ec7 sinh v\u00e0 ti\u1ec7t tr\u00f9ng.<\/p>\n<\/div>\n<\/div>\n<h3 class=\"headLine06\">S\u1ea3n xu\u1ea5t li\u00ean t\u1ee5c<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/service\/engineering\/industrial_field\/pharma_medical-device_cosmetic\/macromolecular_drugs\/mark06.webp\" alt=\"Continuous Production\"><\/div>\n<div class=\"txtInn\">\n<p class=\"wpTag\">S\u1ea3n xu\u1ea5t li\u00ean t\u1ee5c c\u00e1c API sinh h\u1ecdc bao g\u1ed3m nu\u00f4i c\u1ea5y li\u00ean t\u1ee5c (nu\u00f4i c\u1ea5y t\u01b0\u1edbi m\u00e1u) v\u1edbi vi\u1ec7c li\u00ean t\u1ee5c n\u1ea1p m\u00f4i tr\u01b0\u1eddng v\u00e0 thu ho\u1ea1ch ch\u1ea5t l\u1ecfng nu\u00f4i c\u1ea5y, c\u00f9ng v\u1edbi qu\u00e1 tr\u00ecnh tinh ch\u1ebf li\u00ean t\u1ee5c b\u1eb1ng nhi\u1ec1u c\u1ed9t quy m\u00f4 nh\u1ecf th\u1ef1c hi\u1ec7n \u0111\u1ed3ng th\u1eddi qu\u00e1 tr\u00ecnh n\u1ea1p, r\u1eeda v\u00e0 thu h\u1ed3i. S\u1ea3n xu\u1ea5t li\u00ean t\u1ee5c h\u1ee9a h\u1eb9n r\u00fat ng\u1eafn th\u1eddi gian ph\u00e1t tri\u1ec3n do lo\u1ea1i b\u1ecf vi\u1ec7c m\u1edf r\u1ed9ng quy m\u00f4, thu nh\u1ecf thi\u1ebft b\u1ecb v\u00e0 gi\u1ea3m kh\u00f4ng gian c\u01a1 s\u1edf. C\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd nh\u01b0 ICH v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c \u0111ang th\u00fac \u0111\u1ea9y vi\u1ec7c \u00e1p d\u1ee5ng. Tuy nhi\u00ean, so v\u1edbi s\u1ea3n xu\u1ea5t theo l\u00f4, c\u1ea7n c\u00e2n nh\u1eafc c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ki\u1ec3m so\u00e1t (Tr\u1ea1ng th\u00e1i ki\u1ec3m so\u00e1t) v\u00e0 \u0111\u1ecbnh ngh\u0129a l\u00f4.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"sec03\">\n<h2 class=\"headLine05\">\u0110i\u1ec3m m\u1ea1nh c\u1ee7a CM Plus<\/h2>\n<div class=\"comImgArea\">\n<div class=\"subArea\">\n<h3 class=\"headLine06\">\u2460Ph\u01b0\u01a1ng ph\u00e1p K\u1ef9 thu\u1eadt + CM<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"txtInn\">\n<p class=\"wpTag\">Ph\u01b0\u01a1ng ph\u00e1p CM l\u00e0 h\u1ec7 th\u1ed1ng qu\u1ea3n l\u00fd d\u1ef1 \u00e1n t\u00edch h\u1ee3p quan \u0111i\u1ec3m c\u1ee7a kh\u00e1ch h\u00e0ng v\u1edbi c\u00e1c nh\u00e0 thi\u1ebft k\u1ebf \u0111\u1ec3 v\u1eadn h\u00e0nh v\u00e0 qu\u1ea3n l\u00fd d\u1ef1 \u00e1n m\u1ed9t c\u00e1ch minh b\u1ea1ch, \u0111\u1ea3m b\u1ea3o th\u00e0nh c\u00f4ng t\u1eeb c\u00e1c kh\u00eda c\u1ea1nh Ch\u1ea5t l\u01b0\u1ee3ng, Chi ph\u00ed, Giao h\u00e0ng (QCD) + M\u00f4i tr\u01b0\u1eddng, S\u1ee9c kh\u1ecfe, An to\u00e0n (EHS). C\u00e1c chuy\u00ean gia, bao g\u1ed3m Qu\u1ea3n l\u00fd x\u00e2y d\u1ef1ng (CMr) chuy\u00ean v\u1ec1 qu\u1ea3n l\u00fd, l\u00e0m vi\u1ec7c thay m\u1eb7t cho kh\u00e1ch h\u00e0ng..<\/p>\n<div class=\"comLink\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/feature\/\"><span class=\"subSpan\">Qu\u1ea3n l\u00fd x\u00e2y d\u1ef1ng c\u1ee7a CM Plus<\/span><\/a><\/div>\n<\/div>\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_peo07.webp\" alt=\"\u2460Ph\u01b0\u01a1ng ph\u00e1p K\u1ef9 thu\u1eadt + CM\"><\/div>\n<\/div>\n<div class=\"imgInn imgInnR flexB\">\n<div class=\"txtInn\">\n<p class=\"wpTag\">T\u1ea1i CM Plus, ch\u00fang t\u00f4i ti\u1ebfn h\u00e0nh k\u1ef9 thu\u1eadt (thi\u1ebft k\u1ebf) t\u1ea1i ch\u1ed7. Ch\u00fang t\u00f4i c\u00f3 c\u00e1c k\u1ef9 s\u01b0 am hi\u1ec3u v\u1ec1 quy tr\u00ecnh s\u1ea3n xu\u1ea5t, thi\u1ebft b\u1ecb v\u00e0 c\u01a1 s\u1edf nh\u00e0 x\u01b0\u1edfng, x\u00e2y d\u1ef1ng v\u00e0 c\u00e1c ti\u1ec7n \u00edch h\u1ed7 tr\u1ee3 s\u1ea3n xu\u1ea5t (nh\u01b0 h\u1ec7 th\u1ed1ng \u0111i\u1ec7n, HVAC v\u00e0 h\u1ec7 th\u1ed1ng ph\u1ee5 tr\u1ee3). \u0110i\u1ec1u n\u00e0y cho ph\u00e9p ch\u00fang t\u00f4i gi\u00e1m s\u00e1t to\u00e0n b\u1ed9 c\u01a1 s\u1edf nh\u00e0 x\u01b0\u1edfng ngay t\u1eeb giai \u0111o\u1ea1n l\u1eadp k\u1ebf ho\u1ea1ch ban \u0111\u1ea7u, cho ph\u00e9p x\u00e2y d\u1ef1ng c\u00e1c c\u01a1 s\u1edf nh\u00e0 x\u01b0\u1edfng b\u1ed1 tr\u00ed t\u00edch h\u1ee3p v\u00e0 g\u1eafn k\u1ebft.<\/p>\n<\/div>\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img09.webp\" alt=\"\u2460Ph\u01b0\u01a1ng ph\u00e1p K\u1ef9 thu\u1eadt + CM\"><\/div>\n<\/div>\n<\/div>\n<div class=\"subArea\">\n<h3 class=\"headLine06\">\u2461Ph\u1ed1i h\u1ee3p to\u00e0n di\u1ec7n gi\u1eefa thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t v\u00e0 x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y<\/h3>\n<div class=\"imgInn flexB\">\n<div class=\"txtInn\">\n<p class=\"wpTag\">T\u1eadp \u200b\u200btrung v\u00e0o thi\u1ebft k\u1ebf t\u1eeb g\u00f3c \u0111\u1ed9 quy tr\u00ecnh s\u1ea3n xu\u1ea5t, ch\u00fang t\u00f4i th\u1ef1c hi\u1ec7n c\u00e1c thi\u1ebft k\u1ebf b\u1eaft \u0111\u1ea7u t\u1eeb c\u00e1c kh\u00eda c\u1ea1nh n\u1ed9i b\u1ed9 nh\u01b0 x\u00e2y d\u1ef1ng d\u00e2y chuy\u1ec1n thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t, b\u1ed1 tr\u00ed v\u00e0 lu\u1ed3ng\/h\u1eadu c\u1ea7n n\u1ed9i b\u1ed9, d\u1eabn \u0111\u1ebfn vi\u1ec7c t\u1ea1o ra c\u00e1c nh\u00e0 m\u00e1y API (Th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m ho\u1ea1t t\u00ednh) h\u00e0i h\u00f2a v\u1edbi h\u1ec7 th\u1ed1ng s\u1ea3n xu\u1ea5t. K\u1ebf ho\u1ea1ch c\u1ee7a ch\u00fang t\u00f4i c\u0169ng m\u1edf r\u1ed9ng sang c\u00e1c kh\u00eda c\u1ea1nh v\u00f4 h\u00ecnh c\u1ee7a h\u1ec7 th\u1ed1ng s\u1ea3n xu\u1ea5t.<\/p>\n<\/div>\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo14.webp\" alt=\"\u2461Ph\u1ed1i h\u1ee3p to\u00e0n di\u1ec7n gi\u1eefa thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t v\u00e0 x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y\"><\/div>\n<\/div>\n<div class=\"imgInn imgInnR flexB\">\n<div class=\"txtInn\">\n<p class=\"wpTag\">\u0110\u1ed9i ng\u0169 chuy\u00ean gia c\u1ee7a ch\u00fang t\u00f4i bao g\u1ed3m c\u00e1c nh\u00e0 qu\u1ea3n l\u00fd d\u1ef1 \u00e1n v\u00e0 k\u1ef9 s\u01b0 chuy\u00ean nghi\u1ec7p c\u00f3 kinh nghi\u1ec7m trong x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y \u1edf nhi\u1ec1u l\u0129nh v\u1ef1c kh\u00e1c nhau. \u0110i\u1ec1u n\u00e0y cho ph\u00e9p ch\u00fang t\u00f4i qu\u1ea3n l\u00fd to\u00e0n b\u1ed9 ti\u1ebfn \u0111\u1ed9 d\u1ef1 \u00e1n m\u1ed9t c\u00e1ch to\u00e0n di\u1ec7n, bao g\u1ed3m kh\u00f4ng ch\u1ec9 c\u00e1c c\u01a1 s\u1edf h\u1ed7 tr\u1ee3 x\u00e2y d\u1ef1ng v\u00e0 s\u1ea3n xu\u1ea5t m\u00e0 c\u00f2n h\u1ed7 tr\u1ee3 mua s\u1eafm, qu\u1ea3n l\u00fd s\u1ea3n xu\u1ea5t v\u00e0 ph\u1ed1i h\u1ee3p c\u00e1c k\u1ebf ho\u1ea1ch giao h\u00e0ng thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t.<\/p>\n<\/div>\n<div class=\"phoInn\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img11.webp\" alt=\"\u2461Ph\u1ed1i h\u1ee3p to\u00e0n di\u1ec7n gi\u1eefa thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t v\u00e0 x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"sec04\">\n<h2 class=\"headLine05\">D\u1ecbch v\u1ee5 c\u1ee7a CM Plus<\/h2>\n<div class=\"comFlowListBox\">\n<ul class=\"comFlowList\">\n<li class=\"li01 on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/business_concept\/\"><span class=\"txtSpan\">\u00dd t\u01b0\u1edfng Kinh doanh<\/span><\/a><\/li>\n<li class=\"li02 on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/conceptual_design\/\"><span class=\"txtSpan\">Thi\u1ebft k\u1ebf \u00dd t\u01b0\u1edfng<\/span><\/a><\/li>\n<li class=\"li03 on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/basic_design\/\"><span class=\"txtSpan\">Thi\u1ebft k\u1ebf C\u01a1 s\u1edf<\/span><\/a><\/li>\n<li class=\"li04 on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/purocurement\/\"><span class=\"txtSpan\">Mua s\u1eafm thi\u1ebft b\u1ecb<\/span><\/a><\/li>\n<li class=\"li05 on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/detailed-design_construction\/\"><span class=\"txtSpan\">Thi\u1ebft k\u1ebf Chi ti\u1ebft\/ Qu\u1ea3n l\u00fd s\u1ea3n xu\u1ea5t<\/span><\/a><\/li>\n<li class=\"li06 on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/detailed-design_construction\/\"><span class=\"txtSpan\">Thi c\u00f4ng<\/span><\/a><\/li>\n<li class=\"on\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/commissioning_qualification\/\"><span class=\"txtSpan\">V\u1eadn h\u00e0nh th\u1eed<\/span><\/a><\/li>\n<li class=\"liStyle on\"><a href=\"#\" class=\"no\"><span class=\"txtSpan\">V\u1eadn h\u00e0nh<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div class=\"comStepBox\">\n<div class=\"stepBox\">\n<div class=\"lBox\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">01<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img01.webp\" alt=\"Business Concept\"><\/span><\/p>\n<h2 class=\"headLine06\">\u00dd t\u01b0\u1edfng kinh doanh<\/h2>\n<\/div>\n<p class=\"wpTag\">Ch\u00fang t\u00f4i l\u1eafng nghe y\u00eau c\u1ea7u c\u1ee7a kh\u00e1ch h\u00e0ng v\u00e0 t\u1ea1o ra c\u00e1c s\u1ea3n ph\u1ea9m nh\u01b0 danh s\u00e1ch c\u00e1c thi\u1ebft b\u1ecb ch\u00ednh, S\u01a1 \u0111\u1ed3 c\u00f4ng ngh\u1ec7 (PFD) v\u00e0 c\u1ee5 th\u1ec3 h\u00f3a \u00fd t\u01b0\u1edfng b\u1ed1 tr\u00ed \u0111\u1ec3 tr\u1ef1c quan h\u00f3a h\u00ecnh \u1ea3nh \u0111\u1ea7u t\u01b0. D\u1ef1a tr\u00ean c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 t\u1ea1o, ch\u00fang t\u00f4i t\u00ednh to\u00e1n s\u1ed1 ti\u1ec1n \u0111\u1ea7u t\u01b0 g\u1ea7n \u0111\u00fang \u0111\u1ec3 h\u1ed7 tr\u1ee3 c\u00e1c quy\u1ebft \u0111\u1ecbnh \u0111\u1ea7u t\u01b0 (Nghi\u00ean c\u1ee9u kh\u1ea3 thi, F\/S).<\/p>\n<\/div>\n<\/div>\n<div class=\"stepBox\">\n<div class=\"lBox lBox02\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">02<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img02.webp\" alt=\"Conceptual Design\"><\/span><\/p>\n<h2 class=\"headLine06\">Conceptual Design<\/h2>\n<\/div>\n<p class=\"wpTag\">Trong giai \u0111o\u1ea1n l\u1eadp k\u1ebf ho\u1ea1ch c\u01a1 b\u1ea3n (thi\u1ebft k\u1ebf \u00fd t\u01b0\u1edfng), ch\u00fang t\u00f4i bi\u00ean so\u1ea1n c\u00e1c y\u00eau c\u1ea7u v\u00e0 y\u00eau c\u1ea7u c\u1ee7a kh\u00e1ch h\u00e0ng th\u00f4ng qua c\u00e1c cu\u1ed9c th\u1ea3o lu\u1eadn v\u00e0 ghi l\u1ea1i ch\u00fang d\u01b0\u1edbi d\u1ea1ng T\u00f3m t\u1eaft y\u00eau c\u1ea7u c\u1ee7a ng\u01b0\u1eddi d\u00f9ng (URB). Ch\u00fang t\u00f4i c\u0169ng t\u00ednh to\u00e1n chi ph\u00ed d\u1ef1 \u00e1n g\u1ea7n \u0111\u00fang d\u1ef1a tr\u00ean n\u1ed9i dung c\u1ee7a URB.<\/p>\n<\/div>\n<\/div>\n<div class=\"stepBox\">\n<div class=\"lBox lBox03\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">03<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img03.webp\" alt=\"Basic Design\"><\/span><\/p>\n<h2 class=\"headLine06\">Thi\u1ebft k\u1ebf C\u01a1 s\u1edf<\/h2>\n<\/div>\n<p class=\"wpTag\">Trong giai \u0111o\u1ea1n thi\u1ebft k\u1ebf c\u01a1 s\u1edf, d\u1ef1a tr\u00ean n\u1ed9i dung c\u1ee7a URB, ch\u00fang t\u00f4i t\u1ea1o ra c\u00e1c b\u1ea3n v\u1ebd v\u00e0 c\u00e1c th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt c\u1ea7n thi\u1ebft \u0111\u1ec3 ch\u00e0o h\u00e0ng hi\u1ec7u qu\u1ea3. C\u1ee5 th\u1ec3, trong qu\u00e1 tr\u00ecnh thi\u1ebft k\u1ebf, ch\u00fang t\u00f4i t\u1ea1o ra c\u00e1c b\u1ea3n v\u1ebd PFD, P&#038;ID (S\u01a1 \u0111\u1ed3 \u0111\u01b0\u1eddng \u1ed1ng v\u00e0 thi\u1ebft b\u1ecb), b\u1ea3ng d\u1eef li\u1ec7u, l\u1ecbch tr\u00ecnh th\u1eddi gian v\u1eadn h\u00e0nh (OTS) v\u00e0 th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt thi\u1ebft b\u1ecb c\u1ea7n thi\u1ebft cho thi\u1ebft k\u1ebf nh\u00e0 m\u00e1y. Ch\u00fang t\u00f4i c\u0169ng t\u1ed5 ch\u1ee9c c\u00e1c quy \u0111\u1ecbnh v\u00e0 ti\u00eau chu\u1ea9n li\u00ean quan \u0111\u1ebfn thi\u1ebft k\u1ebf v\u00e0 x\u00e2y d\u1ef1ng c\u01a1 s\u1edf, c\u00e1c gi\u1ea5y ph\u00e9p, th\u1ee7 t\u1ee5c hi\u1ec7n h\u00e0nh c\u1ee7a c\u00e1c c\u01a1 quan li\u00ean quan c\u1ee7a ch\u00ednh ph\u1ee7 v\u00e0 c\u00e1c \u0111i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng, h\u1ed7 tr\u1ee3 thi\u1ebft l\u1eadp l\u1ecbch tr\u00ecnh t\u1ed5ng th\u1ec3 c\u1ee7a d\u1ef1 \u00e1n v\u00e0 k\u1ebf ho\u1ea1ch th\u1ef1c hi\u1ec7n t\u1ed5ng th\u1ec3, \u0111\u1ed3ng th\u1eddi h\u1ed7 tr\u1ee3 chu\u1ea9n b\u1ecb v\u00e0 h\u1ed7 tr\u1ee3 ph\u1ed1i h\u1ee3p tr\u01b0\u1edbc v\u1edbi c\u00e1c c\u01a1 quan li\u00ean c\u1ee7a ch\u00ednh ph\u1ee7 v\u00e0 nh\u00e0 cung c\u1ea5p ti\u1ec7n \u00edch c\u00f3 li\u00ean quan.<\/p>\n<\/div>\n<\/div>\n<div class=\"stepBox\">\n<div class=\"lBox lBox04\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">04<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img04.webp\" alt=\"Procurement\"><\/span><\/p>\n<h2 class=\"headLine06\">Mua s\u1eafm thi\u1ebft b\u1ecb<\/h2>\n<\/div>\n<p class=\"wpTag\">Trong giai \u0111o\u1ea1n mua s\u1eafm thi\u1ebft b\u1ecb, \u0111\u1ec3 x\u00e2y d\u1ef1ng m\u1ed9t h\u1ec7 th\u1ed1ng th\u1ef1c hi\u1ec7n t\u1ed1i \u01b0u ph\u00f9 h\u1ee3p v\u1edbi \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a d\u1ef1 \u00e1n, ch\u00fang t\u00f4i nghi\u00ean c\u1ee9u c\u00e1c b\u1ed9 ph\u1eadn \u0111\u1eb7t h\u00e0ng v\u00e0 d\u1ecbch v\u1ee5 v\u00e0 chu\u1ea9n b\u1ecb c\u00e1c th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt ch\u00e0o h\u00e0ng v\u00e0 th\u00f4ng s\u1ed1 k\u1ef9 thu\u1eadt mua s\u1eafm d\u1ef1a tr\u00ean nh\u1eefng c\u00e2n nh\u1eafc n\u00e0y. Sau \u0111\u00f3, ch\u00fang t\u00f4i y\u00eau c\u1ea7u b\u00e1o gi\u00e1 t\u1eeb c\u00e1c c\u00f4ng ty x\u00e2y d\u1ef1ng. Ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 kh\u00e1ch h\u00e0ng trong vi\u1ec7c l\u1ef1a ch\u1ecdn m\u1ed9t c\u00f4ng ty x\u00e2y d\u1ef1ng b\u1eb1ng c\u00e1ch ti\u1ebfn h\u00e0nh \u0111\u00e1nh gi\u00e1 k\u1ef9 thu\u1eadt v\u00e0 \u0111\u00e1nh gi\u00e1 b\u00e1o gi\u00e1 v\u1ec1 c\u00e1c \u0111\u1ec1 xu\u1ea5t do c\u00e1c c\u00f4ng ty x\u00e2y d\u1ef1ng tr\u00ecnh b\u00e0y v\u00e0 t\u00f3m t\u1eaft ch\u00fang trong m\u1ed9t b\u00e1o c\u00e1o.<\/p>\n<\/div>\n<\/div>\n<div class=\"stepBox\">\n<div class=\"lBox lBox05\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">05<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img05.webp\" alt=\"Detailed Design \/ Production Management\"><\/span><\/p>\n<h2 class=\"headLine06\">Thi\u1ebft k\u1ebf chi ti\u1ebft \/ Qu\u1ea3n l\u00fd s\u1ea3n xu\u1ea5t<\/h2>\n<\/div>\n<p class=\"wpTag\">Trong giai \u0111o\u1ea1n thi\u1ebft k\u1ebf chi ti\u1ebft v\u00e0 qu\u1ea3n l\u00fd s\u1ea3n xu\u1ea5t, ch\u00fang t\u00f4i th\u1ef1c hi\u1ec7n gi\u00e1m s\u00e1t thi\u1ebft k\u1ebf \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o c\u00f4ng ty x\u00e2y d\u1ef1ng v\u00e0 c\u00e1c nh\u00e0 cung c\u1ea5p thi\u1ebft b\u1ecb s\u1ea3n xu\u1ea5t c\u1ee5 th\u1ec3 h\u00f3a ph\u1ea3n \u00e1nh trong URB, t\u00e0i li\u1ec7u thi\u1ebft k\u1ebf c\u01a1 s\u1edf v\u00e0 c\u00e1c quy \u0111\u1ecbnh kh\u00e1c nhau trong thi\u1ebft k\u1ebf c\u1ee7a h\u1ecd v\u00e0 \u0111\u1ea3m b\u1ea3o \u0111\u00fang ti\u1ebfn \u0111\u1ed9.<\/p>\n<\/div>\n<\/div>\n<div class=\"stepBox\">\n<div class=\"lBox lBox06\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">06<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img06.webp\" alt=\"Construction and Installation Phase\"><\/span><\/p>\n<h2 class=\"headLine06\">Giai \u0111o\u1ea1n Thi c\u00f4ng v\u00e0 L\u1eafp \u0111\u1eb7t<\/h2>\n<\/div>\n<p class=\"wpTag\">Trong giai \u0111o\u1ea1n thi c\u00f4ng v\u00e0 l\u1eafp \u0111\u1eb7t, ch\u00fang t\u00f4i th\u1ef1c hi\u1ec7n gi\u00e1m s\u00e1t thi c\u00f4ng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00f4ng ty thi c\u00f4ng c\u1ee5 th\u1ec3 h\u00f3a ph\u1ea3n \u00e1nh trong URB, URS, c\u00e1c t\u00e0i li\u1ec7u thi\u1ebft k\u1ebf chi ti\u1ebft v\u00e0 c\u00e1c quy \u0111\u1ecbnh kh\u00e1c nhau trong c\u00f4ng vi\u1ec7c c\u1ee7a h\u1ecd v\u00e0 qu\u1ea3n l\u00fd ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a c\u00e1c c\u01a1 s\u1edf v\u00e0 thi\u1ebft b\u1ecb. Ngo\u00e0i ra, m\u1ed9t ng\u01b0\u1eddi qu\u1ea3n l\u00fd thi c\u00f4ng s\u1ebd c\u01b0 tr\u00fa t\u1ea1i c\u00f4ng tr\u01b0\u1eddng \u0111\u1ec3 qu\u1ea3n l\u00fd t\u00ecnh tr\u1ea1ng thi c\u00f4ng, ti\u1ebfn \u0111\u1ed9 v\u00e0 nh\u1eefng thay \u0111\u1ed5i theo quan \u0111i\u1ec3m c\u1ee7a kh\u00e1ch h\u00e0ng.<\/p>\n<\/div>\n<\/div>\n<div class=\"stepBox\">\n<div class=\"lBox lBox07\">\n<p class=\"barlow\">B\u01af\u1edaC<span class=\"txtSpan\">07<\/span><\/p>\n<\/div>\n<div class=\"rBox\">\n<div class=\"ttl\"><span class=\"img\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_img07.webp\" alt=\"Trial operation\"><\/span><\/p>\n<h2 class=\"headLine06\">Ch\u1ea1y th\u1eed<\/h2>\n<\/div>\n<p class=\"wpTag\">\u0110\u1ec3 th\u1ef1c hi\u1ec7n th\u1ea9m \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng cao v\u00e0 hi\u1ec7u qu\u1ea3, ch\u00fang t\u00f4i cung c\u1ea5p c\u00e1c d\u1ecbch v\u1ee5 ph\u00f9 h\u1ee3p v\u1edbi nhu c\u1ea7u c\u1ee7a kh\u00e1ch h\u00e0ng, gi\u1ea3m b\u1edbt g\u00e1nh n\u1eb7ng cho h\u1ecd b\u1eb1ng c\u00e1ch h\u1ed7 tr\u1ee3 vi\u1ec7c t\u1ea1o ra m\u1ed9t k\u1ebf ho\u1ea1ch th\u1ea9m \u0111\u1ecbnh t\u1ed5ng th\u1ec3 (k\u1ebf ho\u1ea1ch th\u1ea9m \u0111\u1ecbnh g\u1ed1c) v\u00e0 \u0111\u00e1nh gi\u00e1 r\u1ee7i ro t\u1eeb giai \u0111o\u1ea1n l\u1eadp k\u1ebf ho\u1ea1ch v\u00e0 t\u1ea1o ra c\u00e1c \u0111\u1ec1 c\u01b0\u01a1ng cho c\u00e1c b\u01b0\u1edbc Th\u1ea9m \u0111\u1ecbnh (DQ, IQ, OQ, PQ) v\u00e0 h\u1ed7 tr\u1ee3 trong giai \u0111o\u1ea1n th\u1ef1c hi\u1ec7n.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"comTxt operationTtl\">V\u1eadn h\u00e0nh nh\u00e0 m\u00e1y<\/p>\n<\/section>\n<\/div>\n<section class=\"comBorBox comBorBox02\">\n<h2 class=\"headLine04\">D\u1ef1 \u00e1n li\u00ean quan<\/h2>\n<ul class=\"comLinkList\">\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/portfolio\/project_details\/\"><br \/>\n<span class=\"photo\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo05.webp\" alt=\"D\u1ef1 \u00e1n\"><\/span><br \/>\n<span class=\"subSpan\">D\u1ef1 \u00e1n<\/span><br \/>\n<\/a><\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/about_cm_plus\/record\/\"><br \/>\n<span class=\"photo\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo06.webp\" alt=\"Th\u00e0nh t\u1ef1u qua c\u00e1c con s\u1ed1\"><\/span><br \/>\n<span class=\"subSpan\">Th\u00e0nh t\u1ef1u qua c\u00e1c con s\u1ed1<\/span><br \/>\n<\/a><\/li>\n<\/ul>\n<\/section>\n<section class=\"validation\">\n<h2 class=\"headLine04\">Th\u00f4ng tin h\u1eefu \u00edch<\/h2>\n<p class=\"wpTag\">Vui l\u00f2ng tham kh\u1ea3o c\u00e1c b\u00e0i vi\u1ebft li\u00ean quan \u0111\u1ebfn ho\u1ea1t ch\u1ea5t d\u01b0\u1ee3c (API) tr\u00ean trang web ph\u1ed5 bi\u1ebfn th\u00f4ng tin c\u1ee7a ch\u00fang t\u00f4i, \u201cGMP Platform\u201d.<\/p>\n<div class=\"subValidation\">\n<div class=\"comImgBox validationImgBox\">\n<div class=\"photoBox\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo07.webp\" alt=\"\u201cB\u00ed quy\u1ebft x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m: \u1ea4n b\u1ea3n \u0111\u1eb7c bi\u1ec7t\u201d\"><\/div>\n<div class=\"textBox\">\n<h4 class=\"headLine07\">\u201cB\u00ed quy\u1ebft x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m: \u1ea4n b\u1ea3n \u0111\u1eb7c bi\u1ec7t\u201d<\/h4>\n<div class=\"comLinkP02\"><a href=\"https:\/\/www.gmp-platform.com\/article_detail.html?id=6479\" target=\"_blank\" rel=\"noopener noreferrer\">\u201cNh\u1eefng \u0110i\u1ec3m Ch\u00ednh Trong L\u1eadp K\u1ebf Ho\u1ea1ch C\u01a1 B\u1ea3n (Thi\u1ebft K\u1ebf \u00dd t\u01b0\u1edfng) Cho C\u01a1 S\u1edf S\u1ea3n Xu\u1ea5t Ho\u1ea1t Ch\u1ea5t D\u01b0\u1ee3c (API)\u201d<\/a><br class=\"wpTag\"><span class=\"subSpan\">(ti\u1ebfng Nh\u1eadt)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"subValidation\">\n<div class=\"comImgBox validationImgBox\">\n<div class=\"photoBox\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/com_peo05.webp\" alt=\"\u201cB\u00ed quy\u1ebft x\u00e2y d\u1ef1ng nh\u00e0 m\u00e1y d\u01b0\u1ee3c ph\u1ea9m: \u1ea4n b\u1ea3n \u0111\u1eb7c bi\u1ec7t\u201d\"><\/div>\n<div class=\"textBox\">\n<h4 class=\"headLine07 ttlStyle\">Ch\u00fang t\u00f4i \u0111\u00e3 xu\u1ea5t b\u1ea3n m\u1ed9t cu\u1ed1n s\u00e1ch b\u1eb1ng ti\u1ebfng Anh. Vui l\u00f2ng tham kh\u1ea3o tin t\u1ee9c n\u00e0y.<\/h4>\n<div class=\"comLinkP02\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/news\/event\/2023_0609\/\">B\u00e0i thuy\u1ebft tr\u00ecnh t\u1ea1i H\u1ed9i ngh\u1ecb th\u01b0\u1eddng ni\u00ean n\u0103m 2023 c\u1ee7a ISPE Indonesia<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"comOtherBox comOtherBox02\">\n<h2 class=\"headLine04\">D\u1ecbch v\u1ee5 kh\u00e1c<\/h2>\n<ul class=\"comLinkList\">\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/\"><br \/>\n<span class=\"photo\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo02.webp\" alt=\"Consulting\"><\/span><br \/>\n<span class=\"subSpan\">T\u01b0 v\u1ea5n<\/span><br \/>\n<\/a><\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/support_for_training\/\"><br \/>\n<span class=\"photo\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo03.webp\" alt=\"Education\/Training Support\"><\/span><br \/>\n<span class=\"subSpan\">H\u1ed7 tr\u1ee3 \u0110\u00e0o t\u1ea1o\/ Hu\u1ea5n luy\u1ec7n<\/span><br \/>\n<\/a><\/li>\n<li><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/technology_information\/\"><br \/>\n<span class=\"photo\"><img decoding=\"async\" src=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/photo04.webp\" alt=\"Technical Information Services\"><\/span><br \/>\n<span class=\"subSpan\">D\u1ecbch v\u1ee5 Th\u00f4ng tin K\u1ef9 thu\u1eadt<\/span><br \/>\n<\/a><\/li>\n<\/ul>\n<\/section>\n<\/article>\n<aside id=\"sideBar\">\n\t<p class=\"sideTtl\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/\"><span class=\"txtSpan barlow\">D\u1ecbch v\u1ee5<\/span><\/a><\/p>\n\t<ul id=\"menu-service\" class=\"sideList\"><li id=\"menu-item-238\" class=\"jsLi menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-238\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/\">T\u01b0 v\u1ea5n K\u1ef9 thu\u1eadt, Qu\u1ea3n l\u00fd D\u1ef1 \u00e1n<\/a>\n<ul class=\"sub-menu\">\n\t<li id=\"menu-item-253\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-253\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/production_facility\/\">D\u1ecbch V\u1ee5 Tr\u1ecdn G\u00f3i Cho C\u01a1 S\u1edf S\u1ea3n Xu\u1ea5t<\/a><\/li>\n\t<li id=\"menu-item-240\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-240\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/construction_management\/\">Qu\u1ea3n L\u00fd X\u00e2y d\u1ef1ng<\/a><\/li>\n\t<li id=\"menu-item-239\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-239\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/feature\/\">D\u1ecbch V\u1ee5 Qu\u1ea3n L\u00fd X\u00e2y d\u1ef1ng c\u1ee7a CM Plus<\/a><\/li>\n\t<li id=\"menu-item-243\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-243\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/\">Thi c\u00f4ng C\u01a1 s\u1edf s\u1ea3n xu\u1ea5t<\/a>\n\t<ul class=\"sub-menu\">\n\t\t<li id=\"menu-item-245\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-245\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/business_concept\/\">Business Concept<\/a><\/li>\n\t\t<li id=\"menu-item-246\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-246\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/conceptual_design\/\">Conceptual Design<\/a><\/li>\n\t\t<li id=\"menu-item-247\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-247\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/basic_design\/\">Basic Design<\/a><\/li>\n\t\t<li id=\"menu-item-248\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-248\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/purocurement\/\">Procurement<\/a><\/li>\n\t\t<li id=\"menu-item-249\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-249\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/detailed-design_construction\/\">Detailed Design \/ Production Management<\/a><\/li>\n\t\t<li id=\"menu-item-244\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-244\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/project_flow\/commissioning_qualification\/\">Trial Operation -Commissioning &#038; Qualification-<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-254\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-254\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/\">L\u0129nh V\u1ef1c Ho\u1ea1t \u0110\u1ed9ng<\/a>\n\t<ul class=\"sub-menu\">\n\t\t<li id=\"menu-item-242\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-242\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/\">D\u01b0\u1ee3c Ph\u1ea9m v\u00e0 Thi\u1ebft B\u1ecb Y T\u1ebf<\/a>\n\t\t<ul class=\"sub-menu\">\n\t\t\t<li id=\"menu-item-263\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-263\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/sterile_medicine\/\">Sterile Pharmaceutical<\/a><\/li>\n\t\t\t<li id=\"menu-item-264\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-264\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/oral_agent\/\">Oral Drugs<\/a><\/li>\n\t\t\t<li id=\"menu-item-256\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-256\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/medium_molecule_drugs\/\">Medium-Molecule API<\/a><\/li>\n\t\t\t<li id=\"menu-item-257\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-257\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/\">Large-Molecule (Biopharmaceutical) API<\/a><\/li>\n\t\t\t<li id=\"menu-item-813\" class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-813\"><a href=\"\/en\/service\/consulting\/regenerative_medicine\/\">Regenerative Medicine<\/a><\/li>\n\t\t<\/ul>\n<\/li>\n\t\t<li id=\"menu-item-265\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-265\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/food\/\">Th\u1ef1c Ph\u1ea9m<\/a><\/li>\n\t\t<li id=\"menu-item-261\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-261\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/cosmetic\/\">M\u1ef9 Ph\u1ea9m<\/a><\/li>\n\t\t<li id=\"menu-item-260\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-260\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/home-care\/\">S\u1ea3n Ph\u1ea9m Ch\u0103m S\u00f3c Gia \u0110\u00ecnh<\/a><\/li>\n\t\t<li id=\"menu-item-262\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-262\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/semiconductor\/\">B\u00e1n D\u1eabn v\u00e0 Thi\u1ebft B\u1ecb \u0110i\u1ec7n T\u1eed<\/a><\/li>\n\t\t<li id=\"menu-item-259\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-259\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/data_center\/\">Trung T\u00e2m D\u1eef Li\u1ec7u<\/a><\/li>\n\t\t<li id=\"menu-item-258\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-258\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/chemical_plant\/\">Nh\u00e0 M\u00e1y H\u00f3a Ch\u1ea5t<\/a><\/li>\n\t\t<li id=\"menu-item-5871\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5871\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/logistics\/\">H\u1eadu C\u1ea7n<\/a><\/li>\n\t\t<li id=\"menu-item-5870\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5870\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/halal\/\">Ti\u00eau chu\u1ea9n Halal<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-250\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-250\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/overseas_project_support\/\">&#8220;Qu\u1ea3n L\u00fd D\u1ef1 \u00c1n Xuy\u00ean Bi\u00ean Gi\u1edbi &#8220;<\/a>\n\t<ul class=\"sub-menu\">\n\t\t<li id=\"menu-item-251\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-251\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/overseas_project_support\/partners\/\">Alliance Partners in Southeast Asia<\/a><\/li>\n\t\t<li id=\"menu-item-252\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-252\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/overseas_project_support\/partners_2\/\">Collaboration Partners in Europe and America<\/a><\/li>\n\t<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-266\" class=\"jsLi menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-266\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/\">D\u1ecbch v\u1ee5 T\u01b0 v\u1ea5n<\/a>\n<ul class=\"sub-menu\">\n\t<li id=\"menu-item-272\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-272\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/gmdp_consulting\/\">T\u01b0 V\u1ea5n GMP &#038; GDP cho Ng\u00e0nh D\u01b0\u1ee3c<\/a><\/li>\n\t<li id=\"menu-item-271\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-271\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/qms_consulting\/\">H\u1ec7 Th\u1ed1ng Qu\u1ea3n L\u00fd Ch\u1ea5t L\u01b0\u1ee3ng (QMS) cho Thi\u1ebft B\u1ecb Y T\u1ebf<\/a><\/li>\n\t<li id=\"menu-item-274\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-274\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/regulatory_affairs\/\">T\u01b0 V\u1ea5n Ph\u00e1p L\u00fd<\/a><\/li>\n\t<li id=\"menu-item-267\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-267\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/qualification_validation\/\">T\u01b0 V\u1ea5n Th\u1ea9m \u0110\u1ecbnh<\/a><\/li>\n\t<li id=\"menu-item-270\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-270\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/regenerative_medicine\/\">T\u01b0 V\u1ea5n Y H\u1ecdc T\u00e1i T\u1ea1o<\/a><\/li>\n\t<li id=\"menu-item-273\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-273\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/contamination_control_strategy\/\">T\u01b0 V\u1ea5n Chi\u1ebfn L\u01b0\u1ee3c Ki\u1ec3m So\u00e1t \u00d4 Nhi\u1ec5m<\/a><\/li>\n\t<li id=\"menu-item-5658\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5658\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/consulting\/data_integrity\/\">T\u01b0 V\u1ea5n T\u00ednh To\u00e0n V\u1eb9n D\u1eef Li\u1ec7u<\/a><\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-277\" class=\"jsLi noChild menu-item menu-item-type-post_type menu-item-object-page menu-item-277\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/support_for_training\/\">H\u1ed7 tr\u1ee3 \u0110\u00e0o t\u1ea1o\/ Hu\u1ea5n luy\u1ec7n<\/a><\/li>\n<li id=\"menu-item-275\" class=\"jsLi menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-275\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/technology_information\/\">D\u1ecbch v\u1ee5 Th\u00f4ng tin K\u1ef9 thu\u1eadt<\/a>\n<ul class=\"sub-menu\">\n\t<li id=\"menu-item-1872\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1872\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/technology_information\/corressa\/\">CORRESSA<\/a><\/li>\n\t<li id=\"menu-item-5851\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5851\"><a href=\"https:\/\/cm-plus.co.jp\/vn\/service\/technology_information\/energy_management\/\">Gi\u1ea3i Ph\u00e1p Qu\u1ea3n L\u00fd N\u0103ng L\u01b0\u1ee3ng theo Ph\u01b0\u01a1ng Ph\u00e1p \u201cCMP Way\u201d<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/aside><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Trang ch\u1ee7\/ D\u1ecbch v\u1ee5\/ T\u01b0 v\u1ea5n K\u1ef9 thu\u1eadt, Qu\u1ea3n l\u00fd D\u1ef1 \u00e1n\/ Sectors\/ D\u01b0\u1ee3c ph\u1ea9m v\u00e0 Thi\u1ebft b\u1ecb Y t\u1ebf\/ C\u01a1 s\u1edf s\u1ea3n xu\u1ea5t API ph [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":120,"menu_order":37,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"keywords":[9,11],"class_list":["post-133","page","type-page","status-publish","hentry","keywords-sectors","keywords-gmpgdp"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Large-Molecule (Biopharmaceutical) API Manufacturing Facility\uff5cProduction Facilities<\/title>\n<meta name=\"description\" content=\"CM Plus provides total support for the construction of production facilities in the pharmaceutical and medical device fields. By adopting the Engineering + CM (Construction Management) method, we coordinate production equipment and building facilities for high molecular API (Active Pharmaceutical Ingredient) manufacturing facilities. We meet your requirements for quality, cost, and schedule.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Large-Molecule (Biopharmaceutical) API Manufacturing Facility\uff5cProduction Facilities\" \/>\n<meta property=\"og:description\" content=\"CM Plus provides total support for the construction of production facilities in the pharmaceutical and medical device fields. By adopting the Engineering + CM (Construction Management) method, we coordinate production equipment and building facilities for high molecular API (Active Pharmaceutical Ingredient) manufacturing facilities. We meet your requirements for quality, cost, and schedule.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/\" \/>\n<meta property=\"og:site_name\" content=\"CM Plus\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-25T05:56:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/uploads\/2024\/05\/ogp.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"42\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/\",\"url\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/\",\"name\":\"Large-Molecule (Biopharmaceutical) API Manufacturing Facility\uff5cProduction Facilities\",\"isPartOf\":{\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp\",\"datePublished\":\"2024-04-19T07:25:58+00:00\",\"dateModified\":\"2025-09-25T05:56:04+00:00\",\"description\":\"CM Plus provides total support for the construction of production facilities in the pharmaceutical and medical device fields. By adopting the Engineering + CM (Construction Management) method, we coordinate production equipment and building facilities for high molecular API (Active Pharmaceutical Ingredient) manufacturing facilities. We meet your requirements for quality, cost, and schedule.\",\"breadcrumb\":{\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#primaryimage\",\"url\":\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp\",\"contentUrl\":\"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u30db\u30fc\u30e0\",\"item\":\"https:\/\/cm-plus.co.jp\/vn\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Services\",\"item\":\"https:\/\/cm-plus.co.jp\/vn\/service\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Engineering, Project Management\",\"item\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Sectors\",\"item\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Pharmaceuticals and Medical Devices\",\"item\":\"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"Large-Molecule ( Biopharmaceutical ) API Manufacturing Facility\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cm-plus.co.jp\/vn\/#website\",\"url\":\"https:\/\/cm-plus.co.jp\/vn\/\",\"name\":\"CM Plus\",\"description\":\"Your Partner in Facility Construction, Quality Assurance, and Training Support\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cm-plus.co.jp\/vn\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Large-Molecule (Biopharmaceutical) API Manufacturing Facility\uff5cProduction Facilities","description":"CM Plus provides total support for the construction of production facilities in the pharmaceutical and medical device fields. By adopting the Engineering + CM (Construction Management) method, we coordinate production equipment and building facilities for high molecular API (Active Pharmaceutical Ingredient) manufacturing facilities. We meet your requirements for quality, cost, and schedule.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/","og_locale":"ja_JP","og_type":"article","og_title":"Large-Molecule (Biopharmaceutical) API Manufacturing Facility\uff5cProduction Facilities","og_description":"CM Plus provides total support for the construction of production facilities in the pharmaceutical and medical device fields. By adopting the Engineering + CM (Construction Management) method, we coordinate production equipment and building facilities for high molecular API (Active Pharmaceutical Ingredient) manufacturing facilities. We meet your requirements for quality, cost, and schedule.","og_url":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/","og_site_name":"CM Plus","article_modified_time":"2025-09-25T05:56:04+00:00","og_image":[{"url":"https:\/\/cm-plus.co.jp\/vn\/wp-content\/uploads\/2024\/05\/ogp.png"}],"twitter_card":"summary_large_image","twitter_misc":{"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"42\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/","url":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/","name":"Large-Molecule (Biopharmaceutical) API Manufacturing Facility\uff5cProduction Facilities","isPartOf":{"@id":"https:\/\/cm-plus.co.jp\/vn\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#primaryimage"},"image":{"@id":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#primaryimage"},"thumbnailUrl":"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp","datePublished":"2024-04-19T07:25:58+00:00","dateModified":"2025-09-25T05:56:04+00:00","description":"CM Plus provides total support for the construction of production facilities in the pharmaceutical and medical device fields. By adopting the Engineering + CM (Construction Management) method, we coordinate production equipment and building facilities for high molecular API (Active Pharmaceutical Ingredient) manufacturing facilities. We meet your requirements for quality, cost, and schedule.","breadcrumb":{"@id":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/"]}]},{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#primaryimage","url":"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp","contentUrl":"https:\/\/cm-plus.co.jp\/vn\/wp-content\/themes\/cmplus\/image\/common\/key01.webp"},{"@type":"BreadcrumbList","@id":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/macromolecular_drugs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u30db\u30fc\u30e0","item":"https:\/\/cm-plus.co.jp\/vn\/"},{"@type":"ListItem","position":2,"name":"Services","item":"https:\/\/cm-plus.co.jp\/vn\/service\/"},{"@type":"ListItem","position":3,"name":"Engineering, Project Management","item":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/"},{"@type":"ListItem","position":4,"name":"Sectors","item":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/"},{"@type":"ListItem","position":5,"name":"Pharmaceuticals and Medical Devices","item":"https:\/\/cm-plus.co.jp\/vn\/service\/engineering\/field\/pharma_medical-device\/"},{"@type":"ListItem","position":6,"name":"Large-Molecule ( Biopharmaceutical ) API Manufacturing Facility"}]},{"@type":"WebSite","@id":"https:\/\/cm-plus.co.jp\/vn\/#website","url":"https:\/\/cm-plus.co.jp\/vn\/","name":"CM Plus","description":"Your Partner in Facility Construction, Quality Assurance, and Training Support","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cm-plus.co.jp\/vn\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ja"}]}},"_links":{"self":[{"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/pages\/133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/comments?post=133"}],"version-history":[{"count":23,"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/pages\/133\/revisions"}],"predecessor-version":[{"id":6027,"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/pages\/133\/revisions\/6027"}],"up":[{"embeddable":true,"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/pages\/120"}],"wp:attachment":[{"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/media?parent=133"}],"wp:term":[{"taxonomy":"keywords","embeddable":true,"href":"https:\/\/cm-plus.co.jp\/vn\/wp-json\/wp\/v2\/keywords?post=133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}